BDBM605535 (1S,3R)-3-acetamido-N-[5-chloro-4-(5-fluoro-1,1-dimethyl- 2,3-dihydropyrrolo[1,2-a]benzimidazol-7-yl)-2- pyridyl]cyclohexanecarboxamidc::US11673893, Example 13

SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(c(Cl)cn1)-c1cc(F)c2nc3CCC(C)(C)n3c2c1

InChI Key InChIKey=UQZLGOVFSDEYQJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605535   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605535(US11673893, Example 13 | (1S,3R)-3-acetamido-N-[5-...)
Affinity DataIC50: 2.31nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605535(US11673893, Example 13 | (1S,3R)-3-acetamido-N-[5-...)
Affinity DataIC50: 108nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605535(US11673893, Example 13 | (1S,3R)-3-acetamido-N-[5-...)
Affinity DataIC50: 183nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent