BDBM605538 3-({(aR)-6-[7- cyclopropyl-6-(2- hydroxy-2- methylpropoxy)pyra- zolo[1,5-a]pyridine- 3- amido]spiro[3.3]hep- tan-2-yl}oxy)-1- ethyl-1H-pyrazole- 4-carboxamide::US11673886, Example 19

SMILES CCc1nc(O[C@H]2C[C@@]3(C[C@@H](C3)NC(=O)c3cnn4c(C5CC5)c(OCC(C)(C)O)ccc34)C2)c(s1)C(N)=O

InChI Key InChIKey=GCPVZQVGKDEQDM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 605538   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM605538(US11673886, Example 19 | 3-({(aR)-6-[7- cyclopropy...)
Affinity DataIC50: 10.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent