BDBM605583 2-cyclopropyl-4- {[(aR)-6-[6-(2,2,2- trifluoroethoxy)pyra- zolo[1,5-a]pyridine- 3- amido]spiro[3.3]hep- tan-2-yl]oxy}-1,3- thiazole-5- carboxamide::US11673886, Example 62

SMILES NC(=O)c1sc(nc1O[C@H]1C[C@@]2(C[C@@H](C2)NC(=O)c2cnn3cc(OCC(F)(F)F)ccc23)C1)C1CC1

InChI Key InChIKey=NSNSBZFODOETAI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 605583   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM605583(US11673886, Example 62 | 2-cyclopropyl-4- {[(aR)-6...)
Affinity DataIC50: 11.6nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent