BDBM605592 US11673893, Example 62

SMILES Cc1cnc(NC(=O)[C@H]2CCC[C@@H](NC(=O)[C@H]3C[C@@H](O)C3)C2)cc1-c1cc(F)c2nn(C)c(C(C)C)c2c1

InChI Key InChIKey=BMXNNFIAYWHIGH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 605592   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605592BDBM605592(US11673893, Example 62)
Affinity DataIC50: 0.961nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Prelude Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 605592BDBM605592(US11673893, Example 62)
Affinity DataIC50: 133nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent