BDBM605611 US11673893, Example 80

SMILES CC(C)n1cnc2c(F)cc(cc12)-c1cc(NC(=O)[C@H]2CCC[C@H](C2)NC(=O)CC#N)ncc1C

InChI Key InChIKey=FBECJLNJBCQUNR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 605611   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605611(US11673893, Example 80)
Affinity DataIC50: 1.09nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK4/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605611(US11673893, Example 80)
Affinity DataIC50: 640nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK2/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Prelude Therapeutics

US Patent
LigandPNGBDBM605611(US11673893, Example 80)
Affinity DataIC50: 1.18E+3nMAssay Description:The inhibitory activity of compounds was evaluated in vitro using TR-FRET assay with white 384-well low volume microplate (Greiner Bio-One). CDK9/Cyc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
US Patent