BDBM605727 1-N-(4-fluorophenyl)-1-N'-[6-[7- methoxy-6-(1H-pyrazol-4- yl)quinolin-4-yl]oxypyridin-3- yl]cyclopropane-1,1- dicarboxamide::US11673897, Compound 60
SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cn3)c2cc1-c1cn[nH]c1
InChI Key InChIKey=UDAUFHAAGAAGNH-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 605727
Affinity DataIC50: <10nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis
US Patent
Exelixis
US Patent
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer [557-882,H628Q,R794A](Tyrosine-protein kinase Mer)
Exelixis
US Patent
Exelixis
US Patent
Affinity DataIC50: <10nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair