BDBM606152 US11680068, Example 56::tert-butyl 3-[4-amino-3- [2-(methylcarbamoyl)- 1H-indol-6- yl]pyrazolo[3,4- d]pyrimidin-1- yl]azetidine-1- carboxylate

SMILES CNC(=O)c1cc2ccc(cc2[nH]1)-c1nn(C2CN(C2)C(=O)OC(C)(C)C)c2ncnc(N)c12

InChI Key InChIKey=UWMJFWDOZWNGFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 606152   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM606152(tert-butyl 3-[4-amino-3- [2-(methylcarbamoyl)- 1...)
Affinity DataIC50: 363nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM606152(tert-butyl 3-[4-amino-3- [2-(methylcarbamoyl)- 1...)
Affinity DataIC50: 2.52E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent