BDBM608518 6-amino-2-[(3R)-3-amino-3H-spiro[1- benzofuran-2,4'-piperidin]-1'-yl]-5-(2,3- dichlorophenyl)pyrimidine-4- carboxamide::US11696916, Compound 123

SMILES NC(=O)c1nc(N2CCC3(CC2)Oc2ccccc2[C@H]3N)nc(N)c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=CPBAQVNDRVKNJV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608518   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608518BDBM608518(US11696916, Compound 123 | 6-amino-2-[(3R)-3-amino...)
Affinity DataIC50: 15nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
US Patent