BDBM608523 (4P)-6-amino-2-[(3R)-3-amino-3H- spiro[furo[2,3-b]pyridine-2,4'-piperidin]- 1'-yl]-5-(2,3-dichlorophenyl)pyrimidine- 4-carboxamide::US11696916, Compound 128::US11696916, Compound 129

SMILES NC(=O)c1nc(N2CCC3(CC2)Oc2ncccc2[C@H]3N)nc(N)c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=WVQZCPJJNYMBDR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608523   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608523BDBM608523(US11696916, Compound 128 | (4P)-6-amino-2-[(3R)-3-...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608523BDBM608523(US11696916, Compound 128 | (4P)-6-amino-2-[(3R)-3-...)
Affinity DataIC50: 330nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2023
Entry Details
US Patent