BDBM608872 US11702409, Example 21a::US11702409, Example 21b

SMILES CN1Cc2cc(ccc2CC1=O)-c1nn(C2CC3(C2)CN(C3)C(=O)C=C)c(C)c1-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=QILNMQQCDQNCCT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 608872   

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608872(US11702409, Example 21a | US11702409, Example 21b)
Affinity DataIC50: 60nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Novartis

US Patent
LigandPNGBDBM608872(US11702409, Example 21a | US11702409, Example 21b)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays were run using 384-well plates (781207/Greiner) in which one column was designated as the high signal (no inhibition) control, and contained D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent