BDBM608909 (3M)-6-[(6R)-6-amino-5,6- dihydrospiro[cyclopenta[b] pyridine-7,4'-piperidin]-1'- yl]-3-(2,3-dichlorophenyl)- 2,5-dimethyl-3,4- dihydropyrimidin-4-one::US11702392, Compound 75

SMILES Cc1c(N2CCC3(CC2)c2ncccc2C[C@H]3N)nc(C)n(-c2cccc(Cl)c2Cl)c1=O

InChI Key InChIKey=URBIAZABDZPQER-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608909   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608909BDBM608909(US11702392, Compound 75 | (3M)-6-[(6R)-6-amino-5,6...)
Affinity DataIC50: 120nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent