BDBM608911 (3M)-6-[(1R,3R)-1-amino-3- methyl-8-azaspiro[4.5]decan-8- yl]-3-(2,3-dichlorophenyl)-2,5- dimethyl-3,4-dihydropyrimidin-4- one::US11702392, Compound 77

SMILES Cc1c(N2CCC3(CC2)C[C@@H](C)C[C@H]3N)nc(C)n(-c2cccc(Cl)c2Cl)c1=O

InChI Key InChIKey=WOCDEPYHPSYTKV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 608911   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandChemical structure of BindingDB Monomer ID 608911BDBM608911(US11702392, Compound 77 | (3M)-6-[(1R,3R)-1-amino-...)
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent