BDBM609047 3-({5-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-(hydroxymethyl)pyrazin-2-yl}sulfanyl)-2-chlorobenzonitrile. ::US11702411, Compound 22

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cccc(C#N)c3Cl)nc2CO)[C@@H]1N

InChI Key InChIKey=ZIHNJMFPZKGYMZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 609047   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM609047(3-({5-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent