BDBM609051 US11702411, Compound 26::{3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-6-{[3-chloro-2-(3-methanesulfonylazetidin-1-yl)pyridin-4-yl]sulfanyl}pyrazin-2-yl}methanol.

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc(N4CC(C4)S(C)(=O)=O)c3Cl)nc2CO)[C@@H]1N

InChI Key InChIKey=KRMHQFQCAXUESD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 609051   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Revolution Medicines

US Patent
LigandPNGBDBM609051({3-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]...)
Affinity DataIC50: 50nMAssay Description:The inhibition of SHP2 by compounds of the present disclosure (concentrations varying from 0.00005-10 μM) was monitored using an assay in which ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent