BDBM609445 US11702418, Example 10-4

SMILES C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCNCC1)c1cccc(C(F)F)c1C

InChI Key InChIKey=ZFAARKKRLSOLKY-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 609445   

TargetSon of sevenless homolog 1 [564-1049](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM609445(US11702418, Example 10-4)
Affinity DataKi:  0.0800nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent

TargetSon of sevenless homolog 1 [564-1049](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM609445(US11702418, Example 10-4)
Affinity DataIC50: 14nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent