BDBM609683 US11702418, Example 20-5

SMILES C[C@H](Nc1nnc(C)c2cnc(cc12)N1CC2CC(C1)O2)c1cccc(c1F)C(F)(F)C(C)(C)O

InChI Key

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 609683   

TargetSon of sevenless homolog 1 [564-1049](Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM609683(US11702418, Example 20-5)
Affinity DataKi:  0.400nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
US Patent