BDBM609831 (rac)-(2s,4s)-2-(1-(2-Methyl-4-(trifluoromethyl)phenyl)-3- azabicyclo[3.1.0]hexane-3-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one::US11708359, Example 33::US11974987, Example 33

SMILES Cc1cc(ccc1C12CC1CN(C2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2)C(F)(F)F

InChI Key InChIKey=NBLNPVGMSKGLRP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 609831   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609831(US11708359, Example 33 | (rac)-(2s,4s)-2-(1-(2-Met...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609831(US11708359, Example 33 | (rac)-(2s,4s)-2-(1-(2-Met...)
Affinity DataIC50: 2.5nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
US Patent