BDBM609906 (rac)-(2s,4*S)-2-((1*R,5*S,6*R)-6-(3-(tert-Butyl)phenyl)-1-methyl-3- azabicyclo[3.1.0]hexane-3-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one::BDBM609913::US11708359, Example 93::US11974987, Example 99

SMILES CC(C)(C)c1cccc(c1)[C@H]1[C@@H]2CN(C[C@]12C)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=ZXQIHOUZRFSYIK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 609906   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609906((rac)-(2s,4*S)-2-((1*R,5*S,6*R)-6-(3-(tert-Butyl)p...)
Affinity DataIC50: 0.640nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609906((rac)-(2s,4*S)-2-((1*R,5*S,6*R)-6-(3-(tert-Butyl)p...)
Affinity DataIC50: 0.640nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM609906((rac)-(2s,4*S)-2-((1*R,5*S,6*R)-6-(3-(tert-Butyl)p...)
Affinity DataIC50: 0.760nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent