BDBM609946 US11708366, Example 21

SMILES Fc1ccc(cc1)-c1cnc(o1)N1CCC2(CCCC(=O)N2c2ccc(Cl)c(F)c2)CC1

InChI Key InChIKey=ILWDTUKESNZLHX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 609946   

TargetLeukotriene C4 synthase(Human)
Novartis

US Patent
LigandPNGBDBM609946(US11708366, Example 21)
Affinity DataIC50: 4.00E+3nMAssay Description:LTC4 synthase catalyzes the conversion of Leukotriene A4(LTA4) to Leukotriene C4 (LTC4) in the presence of reduced glutathione (GSH) as a co-substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent