BDBM609981 1-N'-(4-fluorophenyl)-1- N-[4-(7-methoxy- pyrido[3,2-d]pyrimidin- 4-yl)oxyphenyl]cyclo- propane-1,1- dicarboxamide::US11708367, Compound 16

SMILES COc1cnc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)ncnc2c1

InChI Key InChIKey=PTCNXTACPMUJGC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 609981   

LigandPNGBDBM609981(US11708367, Compound 16 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetTyrosine-protein kinase Mer [557-882](Human)
Exelixis

US Patent
LigandPNGBDBM609981(US11708367, Compound 16 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 550nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO [473-894](Human)
Exelixis

US Patent
LigandPNGBDBM609981(US11708367, Compound 16 | 1-N'-(4-fluorophenyl)-1-...)
Affinity DataIC50: 550nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent