BDBM609997 1-N'-(4-fluorophenyl)-1-N- (4-pyrido[3,4-d]pyrimidin- 4-yloxyphenyl)cyclopropane- 1,1-dicarboxamide::US11708367, Compound 85

SMILES Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3ncnc4cnccc34)cc2)cc1

InChI Key InChIKey=BAGLRIYGLUAGSG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 609997   

TargetTyrosine-protein kinase receptor UFO [473-894](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609997(1-N'-(4-fluorophenyl)-1-N- (4-pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609997(1-N'-(4-fluorophenyl)-1-N- (4-pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer [557-882](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609997(1-N'-(4-fluorophenyl)-1-N- (4-pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent