BDBM610005 1-N'-(4-fluorophenyl)-1-N- [4-(7-methoxypyrido[4,3- d]pyrimidin-4-yl)oxy- phenyl]cyclopropane-1,1- dicarboxamide::US11708367, Compound 104

SMILES COc1cc2ncnc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cn1

InChI Key InChIKey=SGFLEJHTEKILDO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610005   

LigandPNGBDBM610005(US11708367, Compound 104 | 1-N'-(4-fluorophenyl)-1...)
Affinity DataIC50: 55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetTyrosine-protein kinase Mer [557-882](Human)
Exelixis

US Patent
LigandPNGBDBM610005(US11708367, Compound 104 | 1-N'-(4-fluorophenyl)-1...)
Affinity DataIC50: 55nMAssay Description:Human Mer (residues R557-E882 with H628Q and R794A, 0.7 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl, 250 μM GGMEDIYFEFMGGKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO [473-894](Human)
Exelixis

US Patent
LigandPNGBDBM610005(US11708367, Compound 104 | 1-N'-(4-fluorophenyl)-1...)
Affinity DataIC50: 55nMAssay Description:Human Axl (residues H473-A894 with Q764R, 161 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG (SEQ ID NO. 43), 10 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
US Patent