BDBM610162 (S)-N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamido)-2-methylphenyl)-2-(2-(3-fluoropyrrolidin-1-yl)ethoxy)quinoline-6-carboxamide::US9701664, Example 65

SMILES Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2nc(OCCN3CC[C@H](F)C3)ccc2c1

InChI Key InChIKey=NVGSUPGCHGKWLT-DEOSSOPVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610162   

TargetHeat shock factor protein 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM610162((S)-N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbox...)
Affinity DataIC50:  7nMAssay Description:The cell titre blue viability (Promega, USA) assay provides a homogenous, fluorometric method for estimating the number of viable cells. It uses the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetHeat shock factor protein 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM610162((S)-N-(5-(2,3-dihydrobenzo[b][1,4]dioxine-6-carbox...)
Affinity DataIC50:  29nMAssay Description:U2OS cells (5-8×104 cells/mL) or SK-OV-3 cells (5-8×104 cells/mL) were seeded into 96-well plates and incubated at 37° C. for 48 h. Compounds were th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent