BDBM610417 2-Benzoimidazol-1-yl-1-{(R)-2-hydroxymethyl-4-[2-trifluoromethyl-4-(2-trifluoromethyl-pyrimidin-5-yl)-thiazol-5-yl]-piperazin-1-yl}-ethanone::US10053457, Example 13

SMILES OC[C@H]1CN(CCN1C(=O)Cn1cnc2ccccc12)c1sc(nc1-c1cnc(nc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=WFYDWTNVQOVKAZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610417   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610417(US10053457, Example 13 | 2-Benzoimidazol-1-yl-1-{(...)
Affinity DataIC50: 1.20nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610417(US10053457, Example 13 | 2-Benzoimidazol-1-yl-1-{(...)
Affinity DataIC50: 1.05E+3nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent