BDBM610418 2-(5-Fluoro-indol-1-yl)-1-{(R)-2-hydroxymethyl-4-[2-trifluoromethyl-4-(2-trifluoromethyl-pyrimidin-5-yl)-thiazol-5-yl]-piperazin-1-yl}-ethanone::US10053457, Example 14

SMILES OC[C@H]1CN(CCN1C(=O)Cn1ccc2cc(F)ccc12)c1sc(nc1-c1cnc(nc1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=LQRHNGOTLMNBKG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 610418   

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610418(US10053457, Example 14 | 2-(5-Fluoro-indol-1-yl)-1...)
Affinity DataIC50: 0.700nMAssay Description:The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent

TargetC-X-C chemokine receptor type 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM610418(US10053457, Example 14 | 2-(5-Fluoro-indol-1-yl)-1...)
Affinity DataIC50: 199nMAssay Description:Stock solutions of test compounds are made up at a concentration of 10 mM in DMSO, and serially diluted in PBS containing 0.5% BSA to concentrations ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2023
Entry Details
US Patent