BDBM610456 N-(4-(4-Fluorophenyl)pyridin-3-yl)-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 7

SMILES Fc1ccc(cc1)-c1ccncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=DRDJBBZKDSVNTH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610456   

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610456(US10774086, Example 7 | N-(4-(4-Fluorophenyl)pyrid...)
Affinity DataIC50: 0.600nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610456(US10774086, Example 7 | N-(4-(4-Fluorophenyl)pyrid...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length GST-tagged human recombinant GSK3-alpha using FL-KRREILSRRP[ps]ERYR-NH2 as substrate incubated for 20 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610456(US10774086, Example 7 | N-(4-(4-Fluorophenyl)pyrid...)
Affinity DataIC50: 1.60nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent