BDBM610490 2-Phenyl-N-(4-(2,2,2-trifluoroethoxy)pyrimidin-5-yl)imidazo[1,2-b]pyridazine-8-carboxamide::US10774086, Example 38

SMILES FC(F)(F)COc1ncncc1NC(=O)c1ccnn2cc(nc12)-c1ccccc1

InChI Key InChIKey=NRVJSTPJGPGYAF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 610490   

TargetGlycogen synthase kinase-3 alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610490(US10774086, Example 38 | 2-Phenyl-N-(4-(2,2,2-trif...)
Affinity DataIC50: 1nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610490(US10774086, Example 38 | 2-Phenyl-N-(4-(2,2,2-trif...)
Affinity DataIC50: 3.60nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent

TargetMicrotubule-associated protein tau(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM610490(US10774086, Example 38 | 2-Phenyl-N-(4-(2,2,2-trif...)
Affinity DataIC50: 330nMAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2023
Entry Details
US Patent