BDBM6106 4-[(2,4-Dichloro-5-ethoxyphenyl)amino]-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinoline-3-carbonitrile::4-phenylamino-3-quinolinecarbonitrile 24

SMILES CCOc1cc(Nc2c(cnc3cc(OCC4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl

InChI Key InChIKey=WCXVZXSLSCQTGU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6106   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM6106(4-[(2,4-Dichloro-5-ethoxyphenyl)amino]-6-methoxy-7...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Src kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM6106(4-[(2,4-Dichloro-5-ethoxyphenyl)amino]-6-methoxy-7...)
Affinity DataIC50: 1.40E+3nMAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1/ABL2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM6106(4-[(2,4-Dichloro-5-ethoxyphenyl)amino]-6-methoxy-7...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wyeth Research

LigandPNGBDBM6106(4-[(2,4-Dichloro-5-ethoxyphenyl)amino]-6-methoxy-7...)
Affinity DataIC50: 1.50E+3nMAssay Description:Kinase assays were performed using the europium/APC detection format (LANCE, Perkin Elmer). HTRF is based on the proximity of europium cryptate (dono...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2005
Entry Details Article
PubMed