BDBM612272 N-(4-([1,2,4]triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-6-methoxy-5-((1S,5S)-2-methyl-2,6-diazabicyclo[3.2.0]heptan-6-yl)quinazolin-4-amine Example 46::US11723908, Example 45

SMILES COc1ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c2c1N1C[C@H]2[C@@H]1CCN2C

InChI Key InChIKey=JXQKQNNMNCWTIW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 612272   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612272(US11723908, Example 45 | N-(4-([1,2,4]triazolo[1,5...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612272(US11723908, Example 45 | N-(4-([1,2,4]triazolo[1,5...)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent