BDBM612278 N4-(4-([1,2,4]triazolo[1,5-c]pyrimidin-7-yloxy)-3-methylphenyl)-N6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-5-(3-(dimethylamino)azetidin-1-yl)quinazoline-4,6-diamine::US11723908, Example 54

SMILES CN(C)C1CN(C1)c1c(NC2=NC(C)(C)CO2)ccc2ncnc(Nc3ccc(Oc4cc5ncnn5cn4)c(C)c3)c12

InChI Key InChIKey=JFFXGCPGUQZSLO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 612278   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612278(US11723908, Example 54 | N4-(4-([1,2,4]triazolo[1,...)
Affinity DataIC50: 190nMAssay Description:Inhibition of phosphor HER2 was determined by enzyme-linked immunosorbent assay (ELISA) in BT474 cells. BT474 cell line was purchased from ATCC (cata...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Suzhou Zanrong Pharma

US Patent
LigandPNGBDBM612278(US11723908, Example 54 | N4-(4-([1,2,4]triazolo[1,...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of phosphor wt-EGFR was determined by enzyme-linked immunosorbent assay (ELISA) in NCI H838 cells (ATCC, catalog number CRL-5844). Human P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2023
Entry Details
US Patent