BDBM613472 1-[4-(cyanomethyl)-3-fluoro-1- [(3-hydroxy-2-methyl-4-phenyl- phenyl)methyl]-4-piperidyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 213

SMILES Cc1c(CN2CCC(CC#N)(C(F)C2)n2cc(C(N)=O)c(NC(=O)C3CC3)n2)ccc(c1O)-c1ccccc1

InChI Key InChIKey=UUAGKXIJQQOGAN-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613472   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM613472(1-[4-(cyanomethyl)-3-fluoro-1- [(3-hydroxy-2-methy...)
Affinity DataKi:  0.280nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM613472(1-[4-(cyanomethyl)-3-fluoro-1- [(3-hydroxy-2-methy...)
Affinity DataKi:  0.370nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent