BDBM613519 1-[4-(cyanomethyl)-1-[(4- ethynylphenyl)methyl]-3-fluoro- 4-piperidyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 260

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCN(Cc2ccc(cc2)C#C)CC1F

InChI Key InChIKey=AXRUUNUYHAVRFR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613519   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM613519(1-[4-(cyanomethyl)-1-[(4- ethynylphenyl)methyl]-3-...)
Affinity DataKi:  0.25nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM613519(1-[4-(cyanomethyl)-1-[(4- ethynylphenyl)methyl]-3-...)
Affinity DataKi:  0.350nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent