BDBM613539 1-[1-[(2-chloro-4-ethynyl- phenyl)methyl]-4- (cyanomethyl)-3-fluoro-4- piperidyl]-3- (cyclopropanecarbonylamino) pyrazole-4-carboxamide::US11731943, Example 280

SMILES NC(=O)c1cn(nc1NC(=O)C1CC1)C1(CC#N)CCN(Cc2ccc(cc2Cl)C#C)CC1F

InChI Key InChIKey=SMWDYROYZJTZGK-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613539   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM613539(1-[1-[(2-chloro-4-ethynyl- phenyl)methyl]-4- (cyan...)
Affinity DataKi:  0.300nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM613539(1-[1-[(2-chloro-4-ethynyl- phenyl)methyl]-4- (cyan...)
Affinity DataKi:  0.400nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent