BDBM613829 N-(2-fluorophenyl)-5-(4-(4-fluorophenyl)-1-isopropyl-1H-imidazol-5-yl)furan-2-carboxamide::US11739078, Compound 84::US11739078, Compound A-5

SMILES CC(C)n1cnc(c1-c1ccc(o1)C(=O)Nc1ccccc1F)-c1ccc(F)cc1

InChI Key InChIKey=SIABUCJHEMLWDM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 613829   

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613829(US11739078, Compound 84 | N-(2-fluorophenyl)-5-(4-...)
Affinity DataIC50: 11nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613829(US11739078, Compound 84 | N-(2-fluorophenyl)-5-(4-...)
Affinity DataIC50: 11.1nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613829(US11739078, Compound 84 | N-(2-fluorophenyl)-5-(4-...)
Affinity DataIC50: 12.5nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent