BDBM613832 N-(2-fluorophenyl)-5-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)methyl)-1H-imidazol-5-yl)furan-2-carboxamide::US11739078, Compound 87::US11739078, Compound A-9

SMILES Fc1ccc(cc1)-c1ncn(CC2CCCO2)c1-c1ccc(o1)C(=O)Nc1ccccc1F

InChI Key InChIKey=AJSYWVVZBHGYEW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 613832   

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine IP

US Patent
LigandChemical structure of BindingDB Monomer ID 613832BDBM613832(US11739078, Compound 87 | US11739078, Compound A-9...)
Affinity DataIC50: 76nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine IP

US Patent
LigandChemical structure of BindingDB Monomer ID 613832BDBM613832(US11739078, Compound 87 | US11739078, Compound A-9...)
Affinity DataIC50: 76.5nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine IP

US Patent
LigandChemical structure of BindingDB Monomer ID 613832BDBM613832(US11739078, Compound 87 | US11739078, Compound A-9...)
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant TNIK (1 to 367 residues) using RLGRDKYKTLRQI as substrate incubated for 40 mins in presence of Mg/ATP mix by scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine IP

US Patent
LigandChemical structure of BindingDB Monomer ID 613832BDBM613832(US11739078, Compound 87 | US11739078, Compound A-9...)
Affinity DataIC50: 222nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent