BDBM613867 5-(4-(4-fluorophenyl)-1-(tetrahydrofuran-3-yl)-1H-imidazol-5-yl)-N-(3-methoxypyridin-4-yl)furan-2-carboxamide::US11739078, Compound A-38

SMILES COc1cnccc1NC(=O)c1ccc(o1)-c1c(ncn1C1CCOC1)-c1ccc(F)cc1

InChI Key InChIKey=LMRFBZINQJGYEX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 613867   

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613867(US11739078, Compound A-38 | 5-(4-(4-fluorophenyl)-...)
Affinity DataIC50: 4.21nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613867(US11739078, Compound A-38 | 5-(4-(4-fluorophenyl)-...)
Affinity DataIC50: 10nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent