BDBM613886 US11739078, Compound A-62::US11739078, Compound A-63::rac-5-(4-(4-fluorophenyl)-1-((1R,3S)-3-hydroxycyclopentyl)-1H-imidazol-5-yl)-N-(3-fluoropyridin-4-yl)furan-2-carboxamide

SMILES O[C@H]1CC[C@H](C1)n1cnc(c1-c1ccc(o1)C(=O)Nc1ccncc1F)-c1ccc(F)cc1

InChI Key InChIKey=JHZZTEODBVPOGC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 613886   

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613886(US11739078, Compound A-62 | US11739078, Compound A...)
Affinity DataIC50: 4.72nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613886(US11739078, Compound A-62 | US11739078, Compound A...)
Affinity DataIC50: 9.32nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 4(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613886(US11739078, Compound A-62 | US11739078, Compound A...)
Affinity DataIC50: 64nMAssay Description:The MAP4K4 (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 uM, 10 mM MgAcetate and [gamma-33P-ATP] (specific activity and concentration as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent

TargetTRAF2 and NCK-interacting protein kinase(Human)
Insilico Medicine Ip

US Patent
LigandPNGBDBM613886(US11739078, Compound A-62 | US11739078, Compound A...)
Affinity DataIC50: 93nMAssay Description:The compounds were studied for function as TNIK inhibitors to generate the data of Table 1. The compound was incubated with 8 mM MOPS at pH 7.0, 0.2 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2023
Entry Details
US Patent