BDBM614809 Synthesis of rac-2-((3R,4R)-4-(((6-(cyclopropyl(4-(trifluoromethyl)benzyl)amino)-5-fluoropyrimidin-4-yl)amino)methyl)-3-hydroxypiperidin-1-yl)acetamide A7-1 and chiral separation to A7-1-1 and A7-1-2::US20230271937, Example A7-1::US20230271937, Example A7-1-1

SMILES NC(=O)CN1CC[C@@H](CNc2ncnc(N(Cc3ccc(cc3)C(F)(F)F)C3CC3)c2F)[C@H](O)C1

InChI Key InChIKey=ZJABFXPOYIJVMY-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 614809   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Nuevolution

US Patent
LigandPNGBDBM614809(US20230271937, Example A7-1 | US20230271937, Examp...)
Affinity DataEC50:  0.900nMAssay Description:The HEK293 cell line is co-transfected transiently with two plasmids, one with the RORγ ligand-binding domain fused to galactose-responsive tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetPeroxisome proliferator-activated receptor gamma(Human)
Nuevolution

US Patent
LigandPNGBDBM614809(US20230271937, Example A7-1 | US20230271937, Examp...)
Affinity DataEC50:  1.30nMAssay Description:The HEK293 cell line is co-transfected transiently with two plasmids, one with the RORγ ligand-binding domain fused to galactose-responsive tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent