BDBM614986 US20230271939, Example 24

SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1nccc(C#Cc2cncc3cnn(C)c23)c1F

InChI Key InChIKey=PJWXWWYGJSOSSR-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 614986   

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614986(US20230271939, Example 24)
Affinity DataKi:  2.60nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM614986(US20230271939, Example 24)
Affinity DataIC50: 169nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent