BDBM615180 3-(5,6-difluoro-7-methyl-2-phenyl-1H-indol-3-yl)-N-[(3S,4R)-4-hydroxy-2-oxo-pyrrolidin-3-yl]propanamide (99)::US20230271945, Compound 99

SMILES Cc1c(F)c(F)cc2c(CCC(=O)N[C@H]3[C@H](O)CNC3=O)c([nH]c12)-c1ccccc1

InChI Key InChIKey=JZJZTEUFRPMFHH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 615180   

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 615180BDBM615180(3-(5,6-difluoro-7-methyl-2-phenyl-1H-indol-3-yl)-N...)
Affinity DataIC50: 600nMAssay Description:Briefly, the AlamarBlue active compound, the resazurin, a blue, water soluble, non-toxic and cell permeable molecule, which can be followed by absorb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetApolipoprotein L1(Human)
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 615180BDBM615180(3-(5,6-difluoro-7-methyl-2-phenyl-1H-indol-3-yl)-N...)
Affinity DataIC50: 600nMAssay Description:Apolipoprotein L1 (APOL1) proteins form potassium-permeable cation pores in the plasma membrane. APOL1 risk variants (G1 and G2) induce greater potas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent