BDBM616973 Synthesis of 6-(3-(3-((2-((R)-2,2-difluorocyclopropyl)phenyl)-sulfonyl)propanoyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)nicotinonitrile and 6-(3-(3-((2-((S)-2,2-difluorocyclopropyl)phenyl)sulfonyl)propanoyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)nicotinonitrile::US11752149, Example 35::US11752149, Example 36

SMILES N#Cc1ccc(N2C3CCC2CN(C(=O)CCS(=O)(=O)c2ccccc2[C@H]2CC2(F)F)C3)nc1

InChI Key InChIKey=UARRQBODCVXMBV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 616973   

TargetMuscarinic acetylcholine receptor M1(Human)
Pipeline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 616973BDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 10nMAssay Description:Primary compound plates were prepared in 100% DMSO in opaque 96-well plates (VWR) and serially diluted in half log increments. Secondary compound pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M2(Human)
Pipeline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 616973BDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M4(Human)
Pipeline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 616973BDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 55nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M1(Human)
Pipeline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 616973BDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 550nMAssay Description:Primary compound plates were prepared in 100% DMSO in opaque 96-well plates (VWR) and serially diluted in half log increments. Secondary compound pla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent

TargetMuscarinic acetylcholine receptor M3(Human)
Pipeline Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 616973BDBM616973(US11752149, Example 35 | US11752149, Example 36 | ...)
Affinity DataIC50: 550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2023
Entry Details
US Patent