BDBM619616 (E)-2-(((2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)benzo[d]oxazol-6-yl)oxy)methyl)-3-fluoroprop-2-en-1-amine 4-methylbenzenesulfonate::US11787791, Example 67::US20230295140, Example 67

SMILES NC\C(COc1ccc2nc(oc2c1)N1CC2(COC2)C1)=C/F

InChI Key InChIKey=DAFCAAPRTCOKES-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 619616   

TargetAmine oxidase [copper-containing] 3(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 100nMAssay Description:The capability of compounds described herein to inhibit the enzymatic activity of vascular adhesion protein-1 (VAP-1) was determined by fluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAmine oxidase [copper-containing] 3(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 100nMAssay Description:The capability of compounds described herein to inhibit the enzymatic activity of vascular adhesion protein-1 (VAP-1) was determined by fluorometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 5.50E+3nMAssay Description:The capability of compounds described herein to inhibit MAO was determined using a modified Promega MAO-Glo assay kit. The substrate ((4S)-4,5-dihydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 5.50E+3nMAssay Description:The capability of compounds described herein to inhibit MAO was determined using a modified Promega MAO-Glo assay kit. The substrate ((4S)-4,5-dihydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 5.50E+3nMAssay Description:The capability of compounds described herein to inhibit MAO was determined using a modified Promega MAO-Glo assay kit. The substrate ((4S)-4,5-dihydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Acucela

US Patent
LigandPNGBDBM619616(US20230295140, Example 67 | US11787791, Example 67...)
Affinity DataIC50: 5.50E+3nMAssay Description:The capability of compounds described herein to inhibit MAO was determined using a modified Promega MAO-Glo assay kit. The substrate ((4S)-4,5-dihydr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent