BDBM620112 (R)-3-methyl-4-(7-(3-methyl-1H-pyrazol-5-yl)-4-(1-(methylsulfonyl)cyclopropyl)imidazo[1,5-b]pyridazin-2-yl)morpholine::US20230295166, Compound 31

SMILES Cc1cc(-c2ncc3c(C4(S(C)(=O)=O)CC4)cc(N4CCOC[C@H]4C)nn23)[nH]n1

InChI Key InChIKey=XQFBBSFHODTRBP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620112   

TargetSerine/threonine-protein kinase ATR(Human)
Antengene Discovery

US Patent
LigandChemical structure of BindingDB Monomer ID 620112BDBM620112((R)-3-methyl-4-(7-(3-methyl-1H-pyrazol-5-yl)-4-(1-...)
Affinity DataIC50: 100nMAssay Description:Detection of ATR kinase activity utilized the Mobility shift assay to measure the phosphorylation of the substrate protein FAM-RAD17 (GL, Cat. No. 51...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent