BDBM620123 (R)-3-methyl-4-(3-(3-methyl-1H-pyrazol-5-yl)-7-(2-(methylsulfonyl)propan-2-yl)isothiazolo[4,5-b]pyridin-5-yl)morpholine::US20230295166, Compound 56

SMILES Cc1cc(-c2nsc3c(C(C)(C)S(C)(=O)=O)cc(N4CCOC[C@H]4C)nc23)[nH]n1

InChI Key InChIKey=BSPXFVUNHQJBNW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620123   

TargetSerine/threonine-protein kinase ATR(Human)
Antengene Discovery

US Patent
LigandChemical structure of BindingDB Monomer ID 620123BDBM620123((R)-3-methyl-4-(3-(3-methyl-1H-pyrazol-5-yl)-7-(2-...)
Affinity DataIC50: 100nMAssay Description:Detection of ATR kinase activity utilized the Mobility shift assay to measure the phosphorylation of the substrate protein FAM-RAD17 (GL, Cat. No. 51...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent