BDBM620138 (R)-4-(7-(cyclopropylsulfonyl)-3-(3-methyl-1H-pyrazol-5-yl)isothiazolo[4,5-b]pyridin-5-yl)-3-methylmorpholine::US20230295166, Compound 85

SMILES Cc1cc(-c2nsc3c(S(=O)(=O)C4CC4)cc(N4CCOC[C@H]4C)nc23)[nH]n1

InChI Key InChIKey=VIIIUXVQFHSBKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620138   

TargetSerine/threonine-protein kinase ATR(Human)
Antengene Discovery

US Patent
LigandChemical structure of BindingDB Monomer ID 620138BDBM620138((R)-4-(7-(cyclopropylsulfonyl)-3-(3-methyl-1H-pyra...)
Affinity DataIC50: 100nMAssay Description:Detection of ATR kinase activity utilized the Mobility shift assay to measure the phosphorylation of the substrate protein FAM-RAD17 (GL, Cat. No. 51...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent