BDBM620283 US20230295182, Example 1.15::US20230295182, Example 1.16::tert-butyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3- methoxy-4-(4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H- pyran-2-yl)methyl)-1-oxa-2-azaspiro[4.5]dec-2-en-8-yl)carbamate

SMILES COC1=C(N2C[C@@H](NN2)c2cc(F)c(F)c(F)c2)C(O)=C(CO)O[C@@H]1CC1=NO[C@@]2(C1)CC[C@@H](CC2)NC(=O)OC(C)(C)C

InChI Key InChIKey=FDNLKPZPNCYYFA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 620283   

TargetGalectin-3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM620283(tert-butyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy...)
Affinity DataIC50: 35nMAssay Description:Briefly, compounds are serially diluted in DMSO (working dilutions). ASF-coated 384 well plates are supplemented with 22.8 uL/well of biotinylated hG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetGalectin-3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM620283(tert-butyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy...)
Affinity DataIC50: 340nMAssay Description:Briefly, compounds are serially diluted in DMSO (working dilutions). ASF-coated 384 well plates are supplemented with 22.8 uL/well of biotinylated hG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetGalectin-1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM620283(tert-butyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy...)
Affinity DataIC50: 1.10E+3nMAssay Description:Briefly, compounds are serially diluted in DMSO (working dilutions). ASF-coated 384 well plates are supplemented with 22.8 uL/well of biotinylated hG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent

TargetGalectin-1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM620283(tert-butyl ((5r,8R)-3-(((2R,3R,4S,5R,6R)-5-hydroxy...)
Affinity DataIC50: 2.30E+3nMAssay Description:Briefly, compounds are serially diluted in DMSO (working dilutions). ASF-coated 384 well plates are supplemented with 22.8 uL/well of biotinylated hG...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2023
Entry Details
US Patent