BDBM620734 US20230303540, Example Ex-3.15::US20230303540, Example Ex-3.16::US20230303540, Example Ex-3.17::{8-[6-chloro-2-({1-[3-(methoxymethyl) bicyclo[1.1.1]pentan-1-yl]-1H-pyrazol-4- yl}amino)quinazolin-7-yl]-2-oxa-8-azaspiro [4.5]decan-3-yl}methanol

SMILES COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(COC(CO)C3)CC2)cn1

InChI Key InChIKey=KPPWPRLXQZYKLV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 620734   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620734({8-[6-chloro-2-({1-[3-(methoxymethyl) bicyclo[1.1....)
Affinity DataIC50: 0.218nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620734({8-[6-chloro-2-({1-[3-(methoxymethyl) bicyclo[1.1....)
Affinity DataIC50: 0.227nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620734({8-[6-chloro-2-({1-[3-(methoxymethyl) bicyclo[1.1....)
Affinity DataIC50: 2.28nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent