BDBM620753 6-chloro-N-{1-[3-(methoxymethyl) bicyclo[1.1.1]pentan-1-yl]-1H- pyrazol-4-yl}-7-(1-oxa-8-azaspiro [4.5]decan-8-yl)quinazolin-2-amine::US20230303540, Example Ex-3.34

SMILES COCC12CC(C1)(C2)n1cc(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCCO3)CC2)cn1

InChI Key InChIKey=FXQIQAXYELSQCL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620753   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620753(6-chloro-N-{1-[3-(methoxymethyl) bicyclo[1.1.1]pen...)
Affinity DataIC50: 0.594nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent