BDBM620756 (3R,4R) or (3S,4S) 4-(4-{6-chloro-2- [(1,5-dimethyl-1H-pyrazol-4-yl)amino] quinazolin-7-yl}piperazin-1-yl)-4- methyloxolan-3-ol::US20230303540, Example Ex-3.37::US20230303540, Example Ex-3.43

SMILES Cc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCN(CC2)C2(C)COCC2O)cnn1C

InChI Key InChIKey=OCUNAWGFSMZHML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620756   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620756(US20230303540, Example Ex-3.43 | (3R,4R) or (3S,4S...)
Affinity DataIC50: 0.438nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620756(US20230303540, Example Ex-3.43 | (3R,4R) or (3S,4S...)
Affinity DataIC50: 29.9nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent