BDBM620777 (3R,4R) or (3S,4S) 4-(4-(6-chloro-2- ((5-chloro-1-(3-fluorobicyclo[1.1.1] pentan-1-y])-1H-pyrazol-4-yl)amino) quinazolin-7-yl)piperazin-1-yl) tetrahydrofuran-3-ol::US20230303540, Example Ex-3.58

SMILES OC1COCC1N1CCN(CC1)c1cc2nc(Nc3cnn(c3Cl)C34CC(F)(C3)C4)ncc2cc1Cl

InChI Key InChIKey=VCBLKNWWDXVSDG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 620777   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM620777((3R,4R) or (3S,4S) 4-(4-(6-chloro-2- ((5-chloro-1-...)
Affinity DataIC50: 0.440nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent